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There are many psychological, social, occupational and financial interventions that are helpful in the treatment of schizophrenia, but none of them work unless severely psychotic individuals first have their psychosis controlled with antipsychotic medication.
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Newcomer JW, Weiden PJ, Buchanan RW (2013) Switching antipsychotic medications to reduce adverse event burden in schizophrenia: establishing evidence-based practice.
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They include clozapine (Clozaril, generic), risperidone (Risperdal, generic), olanzapine (Zyprexa, generic), quetiapine (Seroquel), ziprasidone (Geodon), aripiprazole (Abilify), paliperidone (Invega), iloperidone (Fanapt), asenapine (Saphris), and lurasidone (Latuda).
May be necessary to increase the dose of paliperidone when coadministered with a strong inducer of both CYP450 3A4 and P-gp (e.
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Outcomes included relapses (both requiring and not requiring hospitalization) and quality-adjusted life-years (QALYs).
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Recent has shown that, for individuals with Schizophrenia, after stopping their antipsychotic medication 79% had a psychotic relapse by 12 months, 94% by 24 months, and 97% by 36 months.
Randomized patients who received at least one dose of study medication made up the intention-to-treat population.
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The most common adverse reactions in clinical trials in adult subjects with schizophrenia (reported in 5% or more of subjects treated with Paliperidone Extended-Release Tablets and at least twice the placebo rate in any of the dose groups) were extrapyramidal symptoms, tachycardia, and akathisia.
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